Inactivate a variety of viruses, depending on the concentration, With proteins has revealed that, compared to other amino acids,Īrginine is unique in that it enhances the solubility of proteinsĪn additional novel property of arginine is its ability to Characterization of the interaction of this amino acid
Long carbon-containing side chain with a complex guanidinium groupĪt the end. Pilot mouse model studies revealed a marked suppression of death by arginine when the mice were infected with HHV-2 through the vaginal route, followed by an intermittent application of acidic arginine by vaginal instillation.Īrginine is one of the most common 20 natural aminoĪcids and is semi-essential for the human body, carrying a unique In addition, arginine suppressed the multiplication of HHV-2 under the conditions at which its effect on cell viability was insignificant. Although virus inactivation was efficient at an acidic pH, arginine inactivated the virus even at a neutral pH, provided that a higher arginine concentration and prolonged incubation time were used. The effect of arginine was rapid and concentration-dependent. Arginine directly inactivated HHV-2 and characterization of the inactivation demonstrated that 1 M arginine at pH 4.3 inactivated the virus more efficiently compared to 0.1 M citrate or 1 M sodium chloride, indicating that neither acidic pH nor ionic strength alone is sufficient for virus inactivation. We investigated the effects of arginine on the infectivity of human herpesvirus 2 (HHV-2) and the potential application of arginine as a chemotherapeutic agent against genital herpes.
Arginine, among the amino acids, has demonstrated unique properties, including suppression of protein-protein interactions and virus inactivation.
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